Mass transportation provides ideal conditions for disease to spread

twoMass transportation is most probable path for future pandemics. The need for better hygiene is needed. A few studies below support this and are worth taking the time to have a look at.

A measles infection at Kansai International Airport in Japan has recently created concern. Thirty-two employees were found to be infected with measles, creating risk for other employees and travelers alike, who if infected could carry the disease to faraway places. It’s important to recognize the outbreak of illness to keep it from spreading.

The air quality in mass transport buses, especially air-conditioned buses may affect bus drivers who work full time. Microbial air quality in mass transport buses and work-related illness among bus drivers of Bangkok Mass Transit Authority is a study where bus numbers 16, 63, 67 and 166 of the Seventh Bus Zone of Bangkok Mass Transit Authority were randomly selected to investigate for microbial air quality. The standard deviation of the buses studies indicated they had elevated fungal and bacterial counts.

Bacterial contamination on touch surfaces in the public transport system and in public areas of a hospital in London aimed to investigate bacterial contamination on hand-touch surfaces in the public transport system and in public areas of a hospital in central London. The researchers concluded hand-touch sites in London are frequently contaminated with bacteria and can harbor MSSA, but none of the sites tested were contaminated with MRSA. The significance and impact noted is “hand-touch sites can become contaminated with staphylococci and may be fomites for the transmission of bacteria between humans. Such sites could provide a reservoir for community-associated MRSA (CA-MRSA) in high prevalence areas but were not present in London, a geographical area with a low incidence of CA-MRSA.”

The Role of Human Transportation Networks in Mediating the Genetic Structure of Seasonal Influenza in the United States highlight the importance “of utilizing host movement data in characterizing the underlying genetic structure of pathogen populations and demonstrate a need for a greater understanding of the differential effects of host movement networks on pathogen transmission at various spatial scales.”

Previously, at our blog:

Norovirus can be transmitted in variety of ways, including through the air

Norovirus is a seriously contagious virus that can infect anyone, according to Centers for Disease Control. You can get it from an infected person, contaminated food or water, or by touching contaminated surfaces. Additionally, ample research says it can be transmitted through the air. The virus causes your stomach or intestines or both to get inflamed. This leads you to have stomach pain, nausea, and diarrhea and to throw up. These symptoms can be serious for some people, especially young children and older adults, the most vulnerable among us.

Norovirus can have significant economic impact, too. Global Economic Burden of Norovirus Gastroenteritis is a study at PLOS One that “developed a computational simulation model to estimate the economic burden of Norovirus in every country/area (233 total) stratified by World Health Organization region and globally, from the health system and societal perspectives. We considered direct costs of illness (e.g., clinic visits and hospitalization) and productivity losses.” It says that globally, Norovirus resulted in a total of $4.2 billion (95% UI: $3.2–5.7 billion) in direct health system costs and $60.3 billion (95% UI: $44.4–83.4 billion) in societal costs per year. In part it concludes that “the total economic burden is greatest in young children but the highest cost per illness is among older age groups in some regions. These large costs overwhelmingly are from productivity losses resulting from acute illness. . . . Our findings can help identify which age group(s) and/or geographic regions may benefit the most from interventions.”

NoroCORE Food Virology at YouTube is an informative piece that takes a look at food-borne Norovirus illness. NoroCORE and the Perfect Pathogen: USDA-NIFA Efforts to Control Norovirus is a related piece at Contagion Live that reports Norovirus is the leading cause of food-borne illness in the United States, with 5 million of the reported 21 million annual cases linked to contaminated foods. The cost of illness is estimated to be billions of dollars per year.

‘Cruise Ship’ Norovirus Bug Can Spread by Air, Study Finds is a piece at U.S. News and World Report discusses Norovirus and its connection to a series of cruise ship illness. It cites research that finds Norovirus can spread through the air and infect people several feet away.

Norovirus GII.4 Detection in Environmental Samples from Patient Rooms during Nosocomial Outbreaks explores transmission, including through fecal-oral vectors as well as airborne transmission through aerosolized vomitus.


Mass gathering behaviors present unique health challenges

massMass gatherings always are a potential health threat. It’s important that travelers are vaccinated and in the best health possible. This applies to those who attend any events where crowds are present.

Adding a psychological dimension to mass gatherings medicine notes the differences between day-to-day behavior and behavior that surfaces in mass gatherings that affects general health. “Mass gatherings pose distinctive challenges for medicine. One neglected aspect of this is that the behavior of people participating in such events is different from the behavior they exhibit in their everyday lives. This paper seeks to describe a social psychological perspective on the processes shaping people’s behavior at mass gatherings and to explore how these are relevant for an understanding of the processes impacting on the transmission of infection. . . . First, one behaves in terms of one’s understanding of the norms associated with the group. Second, the relationships between group members become more trusting and supportive. Understanding these two behavioral changes is key to understanding how and why mass gathering participants may behave in ways that make them more or less vulnerable to infection transmission. Implications for health education interventions are discussed.”

Half of pilgrims unaware of MERS, at Arab News, reports on a 33-country study about “Pilgrim Awareness of Corona (MERS) Virus,” conducted during the last Haj season. It revealed that about half of the pilgrims were unaware of the virus and prevention methods. . . . The study confirmed the lack of accurate information about the disease among pilgrims, and general lack of awareness, noting the need for effective awareness programs and improved teaching methods about health issues during the Haj season. MERS is a source of concern for the World Health Organization, with the majority of cases emerging from Arab Gulf states, especially Saudi Arabia. This indicates the serious risk of the virus spreading during the pilgrimage. . . The aim of the Saudi study was to assess the awareness of pilgrims of the corona virus, and their responses toward protective standards in dealing with it. The study confirmed that knowledge and awareness is essential and will certainly contribute to the development and improvement of health awareness programs for pilgrims in the future.


Studying disease in humans and animals provides early warning system

downloadZoonotic diseases account for almost 60 percent of all disease among humans. Developing a multi-disciplinary look at disease in humans and animal gives us early warning on pending issues. MERS, SARS and PEDv are all corona viruses hence they model is very similar ways.  In the links below, note the studies that clearly show PEDv and SARS are airborne dangers.

A Unified Framework for the Infection Dynamics of Zoonotic Spillover and Spread says that “disentangling the contribution of animal-to-human from human-to-human transmission is of crucial importance to inform appropriate control measures. The shape of the cumulative number of occurrences can provide indications of the modes of transmission. A concave, saturating profile is an expected outcome due to depletion of susceptibles. In contrast, a convex region in the profile of cumulative number of occurrences suggests that human-to-human transmission plays an important role. Alternative explanations are possible. A convex shape in the cumulative number of occurrences might arise from temporal variations in the model parameters (e.g. probability of contact between humans and rodents, infection prevalence in rodents, infection-response efficiency) and/or in the human population size. A fundamental gap in our current knowledge is the mechanisms governing the transition from spillover to stuttering chain to sustained transmission.”

Database of host-pathogen and related species interactions, and their global distribution discusses “interactions between species, particularly where one is likely to be a pathogen of the other, as well as the geographical distribution of species, have been systematically extracted from various web-based, free-access sources, and assembled with the accompanying evidence into a single database. The database attempts to answer questions such as what are all the pathogens of a host, and what are all the hosts of a pathogen, what are all the countries where a pathogen was found, and what are all the pathogens found in a country. Two datasets were extracted from the database, focussing on species interactions and species distribution, based on evidence published between 1950–2012. The quality of their evidence was checked and verified against well-known, alternative, datasets of pathogens infecting humans, domestic animals and wild mammals. The presented datasets provide a valuable resource for researchers of infectious diseases of humans and animals, including zoonoses.”

Role of two-way airflow owing to temperature difference in severe acute  respiratory syndrome transmission: revisiting the largest nosocomial severe acute respiratory syndrome outbreak in Hong Kong in part concludes that “revisiting the role of air distribution in SARS transmission during the large nosocomial outbreak in (a hospital ward), we found that the two-way airflow effect at the openings plays an important role in bioaerosols transmission. The most likely reason for the two-way airflow effect may be the thermal pressure effect. This paper aimed to investigate the role of air exchange owing to temperature difference in SARS transmission in (the ward) using a validated multi-zone model combining the two-way airflow effect. Within the scope of this research, the following conclusions can be drawn:

·        Air exchange owing to temperature difference played a significant role in SARS transmission during the nosocomial outbreak in Ward 8A.

·        The validated multi-zone model combining the two-way airflow effect may be a better simulation approach than CFD owing to its convenience and accuracy for actual application

·        Reducing the area of the openings between cubicles and corridor (e.g. installing curtains at the openings) may be a more convenient and economical improvement on general ward design.”

At National Geographic Channel, The Big Picture with Kal Penn, talks of the 2003 SARS outbreak in China that quickly became a global epidemic. It attempts to get to the origins of the outbreak to understand how virus spreads.

Also, Evidence of infectivity of airborne porcine epidemic diarrhea virus and detection of airborne viral RNA at long distances from infected herds.

Detroit News sheds light on alarming hygiene issues at Detroit Medical Center

detroit news logoThe Detroit News published a report recently that brought to light shocking hygiene shortcomings at Detroit Medical Center (DMC). The News reported – and the findings weren’t contradicted by DMC administrators, who acknowledge there are problems to fix – that among other things surgeries were cancelled because of unsterile instruments. Time will tell what the hospital does to fix its issues. For the time being, you have to believe patient confidence is seriously shaken. That DMC acknowledges the system needs to be fixed is at least encouraging. What they do, and how quickly, will be something to watch.

Dirty, missing instruments plague DMC surgeries appears in the Detroit News. It says that “more than 200 pages of internal emails and reports indicating that surgeons and staffers have complained for at least 11 years about improperly cleaned, broken and missing instruments. The complaints have continued under the tenure of the for-profit Tenet Healthcare of Dallas, Texas, which acquired the DMC in 2013, the documents show. The records show improperly sterilized tools complicated operations from appendectomies and brain surgeries to cleft palate repair and spinal fusions. Patients were kept under anesthesia for up to an hour as staffers replaced instruments. Dozens of operations were canceled at the last minute, some after anesthesia was administered.” The paper also notes in Hospital records kept from public that the internal reports and emails aren’t made public and were “cloaked in secrecy by Michigan law. State and federal agencies collect a substantial amount of data, but allow hospitals to supply it voluntarily on the condition that much of it is kept confidential. That means only the broadest information — typically about regional rates or whether hospitals are above or below averages — is available to the public.”